Pazin, Wallance Moreira and Furini, Leonardo and Solovyeva, Vita and Lemma, Tibebe and Rubira, Rafael Gonçalves and Jorgensen, Bjarke and Constantino, Carlos Leopoldo and Brewer, Jonathan (2020) Vibrational spectroscopic characterization and coherent anti-stokes Raman spectroscopy (CARS) imaging of artepillin C. Applied spectroscopy, 74. 0003702820904456. ISSN 1943-3530

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Abstract

In the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm–1 , assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From this data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman based methods show potential to visualize the uptake and action of Arteplillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action.

Item Type:	Article
Additional Information:	PMID: 32031016
Subjects:	Science and mathematics > Physics Science and mathematics > Life sciences, biology
Divisions:	Faculty of Mathematics and Science > Institute of Physics (IfP)
Date Deposited:	21 Feb 2020 07:46
Last Modified:	21 Feb 2020 07:46
URI:	https://oops.uni-oldenburg.de/id/eprint/4339
URN:	urn:nbn:de:gbv:715-oops-44205
DOI:	10.1177/0003702820904456
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