Karataş, Suat and Şal, Veysel and Kahramanoğlu, İlker and Demirkıran, Fuat and Beşe, Tugan and Arvas, Macit and Sofiyeva, Nigar and Güralp, Sahin Onur and Uzun, Hafize (2018) Ykl-40 and cancer antigen 72-4 as new and promising diagnostic and prognostic markers for endometrial cancer. Turkish journal of obstetrics and gynecology, 15 (4). pp. 235-242. ISSN 2149-9322

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OBJECTIVE: To determine the predictive role of serum levels of YKL-40 and cancer antigen (CA) 72-4 in the diagnosis of endometrial cancer (EC). MATERIALS AND METHODS: Forty-one patients with EC and 21 women with uterine polyps were evaluated between January and December 2015 in a prospective study. RESULTS: Age, body mass index, preoperative serum YKL-40 and CA 72-4 levels were significantly higher in the malignant group compared with the control group. Serum YKL-40 levels were significantly higher in patients with superficial myometrial invasion and no lymph node involvement (p=0.042; p=0.004). No relationship between clinicopathologic factors and serum CA 72-4 levels was found. CONCLUSION: Serum CA 72-4 and YKL-40 levels are increased in women with EC compared with uterine polyps. Preoperative serum YKL-40 levels may be associated with favorable prognostic factors. The determination of YKL-40 before surgery may be helpful in the evaluation of the regional lymph nodes.

Item Type: Article
Subjects: Technology, medicine, applied sciences > Medicine and health
Date Deposited: 29 May 2019 09:14
Last Modified: 29 May 2019 09:14
URI: https://oops.uni-oldenburg.de/id/eprint/3970
URN: urn:nbn:de:gbv:715-oops-40510

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