Turk J Obstet Gynecol. 2018 Dec;15(4):235-242. doi: 10.4274/tjod.77906. Epub 2019 Jan 9.

Ykl-40 and cancer antigen 72-4 as new and promising diagnostic and prognostic markers for endometrial cancer.

Karataş S¹, Şal V¹, Kahramanoğlu İ², Demirkıran F², Beşe T², Arvas M², Sofiyeva N³, Güralp O⁴, Uzun H⁵.

Author information

1: İstanbul Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.
2: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, İstanbul, Turkey.
3: Yale University Faculty of Medicine, Department of Obstetrics and Gynecology and Reproductive Sciences, New Haven, CT, USA.
4: Klinikum Oldenburg University Hospital, Clinic of Obstetrics and Gynecology, Oldenburg, Germany.
5: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Biochemistry, İstanbul,Turkey.

Abstract

Objective:

To determine the predictive role of serum levels of YKL-40 and cancer antigen (CA) 72-4 in the diagnosis of endometrial cancer (EC).

Materials and Methods:

Forty-one patients with EC and 21 women with uterine polyps were evaluated between January and December 2015 in a prospective study.

Results:

Age, body mass index, preoperative serum YKL-40 and CA 72-4 levels were significantly higher in the malignant group compared with the control group. Serum YKL-40 levels were significantly higher in patients with superficial myometrial invasion and no lymph node involvement (p=0.042; p=0.004). No relationship between clinicopathologic factors and serum CA 72-4 levels was found.

Conclusion:

Serum CA 72-4 and YKL-40 levels are increased in women with EC compared with uterine polyps. Preoperative serum YKL-40 levels may be associated with favorable prognostic factors. The determination of YKL-40 before surgery may be helpful in the evaluation of the regional lymph nodes.