Sander, Carina and Hildebrandt, Helmut and Schlake, Hans-Peter and Eling, Paul and Hanken, Katrin (2017) Subjective cognitive fatigue and autonomic abnormalities in multiple sclerosis patients. Frontiers in neurology, 8. ISSN 1664-2295

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Abstract

Background: Cognitive fatigue and autonomic abnormalities are frequent symptoms in MS. Our model of MS-related fatigue assumes a shared neural network for cognitive fatigue and autonomic failures, i.e., aberrant vagus nerve activity induced by inflammatory processes. Therefore, they should occur in common. Objective: To explore the relationship between cognitive fatigue and autonomic symptoms in MS patients, using self-reported questionnaires. Methods: In 95 MS patients, cognitive fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions and autonomic abnormalities with the Composite Autonomic Symptom Scale-31 (COMPASS-31). We used exploratory correlational analyses and hierarchical regression analysis, controlling for age, depressive mood, disease status, and disease duration, to analyze the relation between autonomic abnormalities and cognitive fatigue. Results: The cognitive fatigue score strongly correlated with the COMPASS-31 score (r = 0.47, p < 0.001). Regression analysis revealed that a model, including the COMPASS-31 domains: pupillomotor, orthostatic intolerance, and bladder, best predict the level of cognitive fatigue (R2 = 0.47, p < 0.001) after forcing the covariates into the model. Conclusion: In MS patients, cognitive fatigue and autonomic dysfunction share a proportion of variance. This supports our model assuming that fatigue might be explained at least partially by inflammation-induced vagus nerve activity.

Item Type: Article
Additional Information: Publiziert mit Hilfe des DFG-geförderten Open Access-Publikationsfonds der Carl von Ossietzky Universität Oldenburg.
Uncontrolled Keywords: multiple sclerosis, cognitive fatigue, Fatigue Scale for Motor and Cognitive Functions, autonomic failures, COMPASS-31, vagus nerve, inflammation
Subjects: Philosophy and psychology > Psychology
Divisions: Faculty of Mathematics and Science > Department of Psychology
Date Deposited: 28 Sep 2017 14:12
Last Modified: 18 Oct 2017 07:53
URI: https://oops.uni-oldenburg.de/id/eprint/3360
URN: urn:nbn:de:gbv:715-oops-34417
DOI: doi:10.3389/fneur.2017.00475
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