Schlichtner, Stephanie and Yasinska, Inna M. and Ruggiero, Sabrina and Berger, Steffen M. and Aliu, Nijas and Prunk, Mateja and Kos, Janko and Meyer, N. Helge and Gibbs, Bernhard F. and Fasler-Kan, Elizaveta and Sumbayev, Vadim V. (2022) Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes. Frontiers in Medicine, 9. ISSN 2296-858X

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Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking the ability of cytotoxic immune lymphoid cells to attack cancer cells and, ultimately, to fully suppress anti-tumor immunity. One of the more recently discovered immune checkpoint proteins is V-domain Ig-containing suppressor of T cell activation (VISTA), which plays a crucial role in anti-cancer immune evasion pathways. The biochemical mechanisms underlying regulation of VISTA expression remain unknown. Here, we report for the first time that VISTA expression is controlled by the transforming growth factor beta type 1 (TGF-β)-Smad3 signaling pathway. However, in T lymphocytes, we found that VISTA expression was differentially regulated by TGF-β depending on their immune profile. Taken together, our results demonstrate the differential biochemical control of VISTA expression in human T cells and various types of rapidly proliferating cells, including cancer cells, fetal cells and keratinocytes.

Item Type: Article
Additional Information: Publiziert mit Hilfe des DFG-geförderten Open Access-Publikationsfonds der Carl von Ossietzky Universität Oldenburg.
Uncontrolled Keywords: immune checkpoint, VISTA, anti-cancer immunity, T lymphocytes, galectin-9
Subjects: Technology, medicine, applied sciences > Medicine and health
Divisions: Faculty of Medicine and Health Sciences > Department of Human Medicine
Date Deposited: 26 Oct 2023 10:46
Last Modified: 26 Oct 2023 10:46
URN: urn:nbn:de:gbv:715-oops-59710
DOI: doi:10.3389/fmed.2022.790995

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