Thome, Ina and Lacle, Raphael and Voß, Andreas and Bortolussi, Ginette and Pantazis, Georgios and Schmidt, Ansgar and Conrad, Catharina and Jacob, Ralf and Timmesfeld, Nina and Bartsch, Jörg W. and Pagenstecher, Axel (2020) Neoplastic cells are the major source of MT-MMPs in IDH1-mutant glioma, thus enhancing tumor-cell intrinsic brain infiltration. Cancers, 12 (9). pp. 1-17. ISSN 2072-6694

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Abstract

Most primary brain tumors infiltrate the surrounding brain even before the time of diagnosis and therefore cannot be removed completely. Matrix metalloproteases can degrade the extracellular proteins of the brain and thereby allow for the brain infiltration of glioma cells. Here, we demonstrate that tumor cells are the major source of several metalloproteases and as such responsible for the malignant behavior of gliomas. Our findings suggest that, controlling metalloproteases might be a promising therapeutic avenue in the treatment of glioma.

Item Type:	Article
Uncontrolled Keywords:	Glioblastoma; MT-MMPs; Glioma; Brain Infiltration
Subjects:	Science and mathematics > Life sciences, biology Technology, medicine, applied sciences > Medicine and health
Divisions:	Faculty of Medicine and Health Sciences > Department of Human Medicine
Date Deposited:	12 Feb 2021 13:25
Last Modified:	12 Feb 2021 13:25
URI:	https://oops.uni-oldenburg.de/id/eprint/4887
URN:	urn:nbn:de:gbv:715-oops-49681
DOI:	10.3390/cancers12092456
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