Dijkstra, Dorieke J. and Verkaik-Schakel, Rikst Nynke and Eskandar, Sharon and Limonciel, Alice and Stojanovska, Violeta and Scherjon, Sicco A. and Plösch, Torsten (2020) Mid-gestation low-dose LPS administration results in female-specific excessive weight gain upon a western style diet in mouse offspring. Scientific Reports, 10 (1). pp. 1-14. ISSN 2045-2322

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Abstract

Gestational complications, including preeclampsia and gestational diabetes, have long-term adverse consequences for offspring's metabolic and cardiovascular health. A low-grade systemic inflammatory response is likely mediating this. Here, we examine the consequences of LPS-induced gestational inflammation on offspring's health in adulthood. LPS was administered to pregnant C57Bl/6J mice on gestational day 10.5. Maternal plasma metabolomics showed oxidative stress, remaining for at least 5 days after LPS administration, likely mediating the consequences for the offspring. From weaning on, all offspring was fed a control diet; from 12 to 24 weeks of age, half of the offspring received a western-style diet (WSD). The combination of LPS-exposure and WSD resulted in hyperphagia and increased body weight and body fat mass in the female offspring. This was accompanied by changes in glucose tolerance, leptin and insulin levels and gene expression in liver and adipose tissue. In the hypothalamus, expression of genes involved in food intake regulation was slightly changed. We speculate that altered food intake behaviour is a result of dysregulation of hypothalamic signalling. Our results add to understanding of how maternal inflammation can mediate long-term health consequences for the offspring. This is relevant to many gestational complications with a pro-inflammatory reaction in place.

Item Type:	Article
Uncontrolled Keywords:	Feeding behaviour, Metabolic diseases, Reproductive biology, Experimental models of disease, Preclinical research
Subjects:	Technology, medicine, applied sciences > Medicine and health
Divisions:	Faculty of Medicine and Health Sciences > Department of Human Medicine
Date Deposited:	12 Feb 2021 13:24
Last Modified:	12 Feb 2021 13:24
URI:	https://oops.uni-oldenburg.de/id/eprint/4878
URN:	urn:nbn:de:gbv:715-oops-49598
DOI:	10.1038/s41598-020-76501-8
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