Schulze, Marcel and Sörös, Peter and Vogel, Wolfgang and Münte, Thomas Frank and Müller, Helge H. O. and Philipsen, Alexandra
(2018)
Impact of bariatric surgery on neural food processing and cognition: an fMRI study.
BMJ open, 8 (9).
e022375.
ISSN 2044-6055
Abstract
Introduction The Roux-en-Y gastric bypass (RYGB) is one
of the most widely used techniques for bariatric surgery.
After RYGB, weight loss up to 50%–70% of excess body
weight, improvement of insulin-resistance, changes
in food preferences and improvements in cognitive
performance have been reported. This protocol describes a
longitudinal study of the neural correlates associated with
food-processing and cognitive performance in patients
with morbid obesity before and after RYGB relative to lean
controls.
Methods and analysis This study is a pre–post case–
control experiment. Using functional MRI, the neural
responses to food stimuli and a working memory task will
be compared between 25 patients with obesity, pre and
post RYGB, and a matched, lean control group. Resting
state fMRI will be measured to investigate functional brain
connectivity. Baseline measurements for both groups will
take place 4 weeks prior to RYGB and 12 months after
RYGB. The effects of RYGB on peptide tyrosine tyrosine and
glucagon-like polypeptide-1 will also be determined.
Ethics and dissemination The project has received
ethical approval by the local medical ethics committee of
the Carl-von-Ossietzky University of Oldenburg, Germany
(registration: 2017-073). Results will be published in
a peer-reviewed journal as original research and on
international conferences.
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