Wichmann, Heidi and Brinkhoff, Thorsten and Simon, Meinhard and Richter-Landsberg, Christiane (2016) Dimethylsulfoniopropionate promotes process outgrowth in neural cells and exerts protective effects against tropodithietic acid. Marine drugs, 14(5) (89). ISSN 1660-3397

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The marine environment harbors a plethora of bioactive substances, including drug candidates of potential value in the field of neuroscience. The present study was undertaken to investigate the effects of dimethylsulfoniopropionate (DMSP), produced by several algae, corals and higher plants, on cells of the mammalian nervous system, i.e., neuronal N2a and OLN-93 cells as model system for nerve cells and glia, respectively. Additionally, the protective capabilities of DMSP were assessed in cells treated with tropodithietic acid (TDA), a marine metabolite produced by several Roseobacter clade bacteria. Both cell lines, N2a and OLN-93, have previously been shown to be a sensitive target for the action of TDA, and cytotoxic effects of TDA have been connected to the induction of oxidative stress. Our data shows that DMSP promotes process outgrowth and microtubule reorganization and bundling, accompanied by an increase in alpha-tubulin acetylation. Furthermore, DMSP was able to prevent the cytotoxic effects exerted by TDA, including the breakdown of the mitochondrial membrane potential, upregulation of heat shock protein Hsp32 and activation of the extracellular signal-regulated kinases 1/2 (ERK1/2). Our study points to the conclusion that DMSP provides an antioxidant defense, not only in algae but also in mammalian neural cells.

Item Type: Article
Additional Information: Publiziert mit Hilfe des DFG-geförderten Open Access-Publikationsfonds der Carl von Ossietzky Universität Oldenburg.
Uncontrolled Keywords: nerve cells; oligodendrocytes; dimethylsulfoniopropionate; tropodithietic acid; neuroprotection; process outgrowth; Roseobacter clade bacteria
Subjects: Science and mathematics > Life sciences, biology
Divisions: Faculty of Medicine and Health Sciences > Department of Neuro Sciences
Date Deposited: 17 Jan 2017 10:57
Last Modified: 23 Jun 2017 12:51
URI: https://oops.uni-oldenburg.de/id/eprint/2929
URN: urn:nbn:de:gbv:715-oops-30103
DOI: 10.3390/md14050089

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