Abdullaeva, Oliya S. and Schulz, Matthias and Balzer, Frank and Parisi, Juergen and Lützen, Arne and Dedek, Karin and Schiek, Manuela (2016) Photoelectrical stimulation of neuronal cells by an organic semiconductor-electrolyte interface. Langmuir, 32 (33). pp. 8533-8542. ISSN 0743-7463

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As a step toward the realization of neuroprosthetics for vision restoration, we follow an electrophysiological patch-clamp approach to study the fundamental photoelectrical stimulation mechanism of neuronal model cells by an organic semiconductor−electrolyte interface. Our photoactive layer consisting of an anilino-squaraine donor blended with a fullerene acceptor is supporting the growth of the neuronal model cell line (N2A cells) without an adhesion layer on it and is not impairing cell viability. The transient photocurrent signal upon illumination from the semiconductor−electrolyte layer is able to trigger a passive response of the neuronal cells under physiological conditions via a capacitive coupling mechanism. We study the dynamics of the capacitive transmembrane currents by patch-clamp recordings and compare them to the dynamics of the photocurrent signal and its spectral responsivity. Furthermore, we characterize the morphology of the semiconductor−electrolyte interface by atomic force microscopy and study the stability of the interface in dark and under illuminated conditions.

Item Type: Article
Subjects: Science and mathematics > Physics
Science and mathematics > Life sciences, biology
Divisions: Faculty of Mathematics and Science > Department of Biology and Environmental Sciences (IBU)
Faculty of Mathematics and Science > Institute of Physics (IfP)
Date Deposited: 20 Dec 2016 12:21
Last Modified: 20 Dec 2016 12:21
URI: https://oops.uni-oldenburg.de/id/eprint/2880
URN: urn:nbn:de:gbv:715-oops-29617
DOI: 10.1021/acs.langmuir.6b02085

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